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Re:MDMA-assisted couples therapy investigated in pilot trial by majormajor on Wednesday December 09, 2020 @05:17PM (#25366047)
> But if you've ever done MDMA you'd certainly know it was a placebo, so it feels like these are people who never had, but imagined what they thought it ought to be like.

There have been times when the effect of coffee or marijauna hits me after a few sips/a bite of an edible, which feels placebo-y. But then I'm aware that it seems to be too fast, even as I start to feel it so fast, so could that still be a placebo effect?

I don't know, but it confuses me.

Re:MDMA-assisted couples therapy investigated in pilot trial by Wirerack on Wednesday December 09, 2020 @08:32PM (#25368383)
I too have noticed this when I tried an edible. An almost imperceptible high that occurred for a few minutes just after ingestion. However this should be impossible as the time taken to metabolize THC is typically an hour or two.

My only guess is that some of the THC is absorbed orally, but in a small quantity. That might explain the high feeling. Can't say I would know what the mechanism for this is, just a guess.

Re:MDMA-assisted couples therapy investigated in pilot trial by pmoriarty on Wednesday December 09, 2020 @09:02PM (#25368636)
There are quite a few reports of people experiencing powerful somatic effects just from the anticipation of taking a drug, without having taken any.

Experiencing an unusual taste in the mouth is common. I've heard of some people feeling a need to vacate their bowels when they are anticipating taking a drug.

So it's not at all surprising that when you actually take a drug you experience something right away, even before the drug has had time to work.

The mind is a powerful thing.

This is a completely untested hypothesis, but I wonder if these kinds of effects are somehow related to hallucinogen persisting perception disorder (HPPD). People experience some really powerful effects under the influence, and maybe the mind somehow learns to reproduce some of these effects on its own.