Consider game like Dark Souls 3, it has very simple anti-cheat system and trusts the client completely. Yet you rarely see actually cheaters online, this is purely a social problem.
You can search any rootkit based anti-cheat software and find just how many people have issues with them. Just some examples from the infamous riot vanguard which developers boast it being "user-friendly" rootkit.
* https://www.reddit.com/r/pcgaming/comments/gead0n/riot_vangu...
* https://www.reddit.com/r/VALORANT/comments/geqc73/have_you_d...
* https://www.reddit.com/r/VALORANT/comments/gbebt0/if_riot_is...
* https://www.reddit.com/r/VALORANT/comments/g5aem3/vanguard_a...
Anyway, it seems to me that most of those people just need to update their fan control programs. One example I saw was CPU-z which had a CVE in their driver a few years ago. They are using drivewrs with known vulnerabilities. You also need to consider that some cheaters will also spread mis-information.