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Re:The Death of Tony Hsieh: A Spiral of Alcohol, Drugs and E... by okareaman on Sunday December 06, 2020 @08:39PM (#25328554)
You start getting incoherent after heavy use, even when not currently using. People who know you notice. Jewel said she left an event early because she was upset to see Tony was acting that way. It takes 4-6 days to recover from a heavy run, including getting feeling back in your nerve endings. Taking B vitamins help.
Re:The Death of Tony Hsieh: A Spiral of Alcohol, Drugs and E... by Scoundreller on Sunday December 06, 2020 @11:36PM (#25329349)
I’d go further and say everyone taking nitrous oxide should be taking b12 supplements.
Re:The Death of Tony Hsieh: A Spiral of Alcohol, Drugs and E... by okareaman on Monday December 07, 2020 @12:27AM (#25329565)
Absolutely. I have pernicious anemia now (need B12 shots) that I didn't have before, at least not diagnosed when younger.
Re:The Death of Tony Hsieh: A Spiral of Alcohol, Drugs and E... by selestify on Sunday December 06, 2020 @11:35PM (#25329343)
How much is a "heavy run"? Another commenter mentioned buying many cases.
Re:The Death of Tony Hsieh: A Spiral of Alcohol, Drugs and E... by Scoundreller on Sunday December 06, 2020 @11:46PM (#25329390)
Some rather serious side effects have been described in a vegetarian (probably already b12 deficient) after just an hour of continuous exposure.

While that was in a clinical setting, it can be quick if you’re already at risk.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

Re:The Death of Tony Hsieh: A Spiral of Alcohol, Drugs and E... by okareaman on Monday December 07, 2020 @12:30AM (#25329585)
I'd need 4 to 6 days to recover after doing 2 cases or 1200 whippets. I'd be extremely sick for the first 2 or 3 days.