So they bootstrapped the phases of the X-ray diffraction pattern with the phases from AlphaFold. This does mean, though, that we must be critical - it is possible that they are converging to nonsense that AlphaFold has generated. To be truly sure, you must have some sort of independent confirmation. Might still be "good enough" depending on what your application is.
https://news.ycombinator.com/reply?id=25262458&goto=threads%...
So they bootstrapped the phases of the X-ray diffraction pattern with the phases from AlphaFold. This does mean, though, that we must be critical - it is possible that they are converging to nonsense that AlphaFold has generated. To be truly sure, you must have some sort of independent confirmation. Might still be "good enough" depending on what your application is.