I would be shocked if any state made vaccination mandatory today (and I'd probably also be surprised if any of those SCOTUS decisions would be upheld/made today although, given the circumstances around Korematsu, who knows).

But might universities and workplaces make it a requirement once a vaccine becomes readily available? That wouldn't surprise me in the slightest. And that may force some tough decisions on skeptics who would have liked to see more time. (Which doesn't include myself.)