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Re:AlphaFold: a solution to a 50-year-old grand challenge in... by sanxiyn on Monday November 30, 2020 @12:16PM (#25256164)
I expect this to be quickly replicated once published. Training data is public and training compute is not enormous and AlphaFold of 2018 did get replicated.
Re:AlphaFold: a solution to a 50-year-old grand challenge in... by dekhn on Monday November 30, 2020 @12:23PM (#25256254)
CASP typically works this way: one person "wins" by getting a slightly higher score than everybody else. Two years later, the top teams have all duplicated the previous winner's tech, and two years after that, there's a github you can download and run on your GPU to reproduce everything.
Re:AlphaFold: a solution to a 50-year-old grand challenge in... by kxs on Monday November 30, 2020 @12:26PM (#25256288)
How do you define enormous? "It uses approximately 128 TPUv3 cores (roughly equivalent to ~100-200 GPUs) run over a few weeks". Also last time it took about a year for good replications to pop up.
Re:AlphaFold: a solution to a 50-year-old grand challenge in... by mrDmrTmrJ on Monday November 30, 2020 @12:35PM (#25256404)
A year is a fast time to replication in many scientific fields.

While substantial, the resources here are well within reach of many labs, research institutes, and organizations. For this result this big, I'd guess we'll have 2-6 additional implementations in the next 18 months. The problem has been 'open' for 40+ years, so that's lightening fast!

Re:AlphaFold: a solution to a 50-year-old grand challenge in... by elcritch on Monday November 30, 2020 @12:59PM (#25256734)
A couple of hundred GPU's is well within the reach of many even moderately well heeled research institutes. It'd seem that about 3 weeks of compute time with 128 TPU v3's would be about $170,311.68.
Re:AlphaFold: a solution to a 50-year-old grand challenge in... by kxs on Monday November 30, 2020 @01:22PM (#25257055)
But of course that cost would only be for the final model. Anyway, I think I am just living in a different world... :-) We could never compete with that
Re:AlphaFold: a solution to a 50-year-old grand challenge in... by elcritch on Monday November 30, 2020 @01:26PM (#25257105)
Yah, big grant money. Now the grad students programming the open source clones will only make approximately $0.56, or 4.2 Ramen packs, for their effort. ;)
Re:AlphaFold: a solution to a 50-year-old grand challenge in... by sdenton4 on Monday November 30, 2020 @02:12PM (#25257603)
Also with keeping in mind that once a good open source model is available, researchers with less resources can still use it to fine tune and get new results for far cheaper than training a new model from scratch.
Re:AlphaFold: a solution to a 50-year-old grand challenge in... by intpx on Monday November 30, 2020 @01:27PM (#25257116)
or cryptominers
Re:AlphaFold: a solution to a 50-year-old grand challenge in... by dragontamer on Monday November 30, 2020 @12:57PM (#25256708)
A lot of labs have access to the various strategic supercomputers of the USA.

Ex: Summit has 27,648 V100 GPUs (and those V100s have Tensor units). If you're saying that only 200 GPUs are needed to replicate the experiment, that doesn't even use up 1% of Summit's available utilization.