Of course. Facebook is a serious cat & mouse with adblocking. I once tried to look at an ad with the devtools inspector and the ad the disappeared. Somehow FB was detecting the inspector and remove the ad so it couldn't be inspected. (Well I'm sure that could be used against them)

https://old.reddit.com/r/uBlockOrigin/comments/fnkwa4/facebo...

There is new-ish one that might work.

EDIT: No, now it's only the text that identifies it as "Sponsored" the rest of the ad does not disappear.

EDIT2: For an example here is how the word "Sponsored" is represented in the DOM:

  <span aria-labelledby="jsc_c_cm" aria-label="Sponsored" class="j1lvzwm4 stjgntxs ni8dbmo4 q9uorilb gpro0wi8"><span
        aria-label="Sponsored" aria-labelledby="jsc_c_cn"></span><span
        class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4">S<span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">n</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">t</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">S</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">n</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">p</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4">p</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4">o</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4">n</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">i</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4">s</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">i</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4">o</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">S</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4">r</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">o</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">e</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">l</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">o</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4">e</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">c</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">n</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">s</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">c</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">s</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">o</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">r</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">e</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4">d</span><span
            class="b6zbclly myohyog2 l9j0dhe7 aenfhxwr l94mrbxd ihxqhq3m nc684nl6 t5a262vz sdhka5h4"
            style="position: absolute; top: 3em;">d</span></span></span>