I have a dual monitor setup at home--one landscape (iMac) and one portrait. This is basically the same setup I've used for more than a decade. (I tried 3 monitors once and it was too much.) However, if I were starting over without a built-in monitor, I would seriously look at one of the big/wide curved screen monitors. A number of people I know prefer those to dual monitors.

On the flip side, it is nice to have one screen with video conferencing set up to be as near the camera as possible. But I actually tend to do notes and so forth on a laptop while I'm conferencing because my mechanical keyboard on my desktop is very loud.