We use it for a large enterprise webapp. We have a component library that uses react and applies the correct classes to the component there. I came from mostly using styled-components (CSS-in-JS) and tailwind has worked pretty well for us. The benefit of tailwind over css-in-js is primarily one of performance.

The downside is all styling gets shoved into the `className` prop which isn't great. If I had full automonomy to choose the css "framework" I would probably opt for something like `rebass` https://rebassjs.org/