If you use numba (or cython, c extensions, etc) you can make them run without requiring that they hold the GIL, and they can run in parallel. Here's an example that should keep a CPU pegged at 100% utilization for a while:

  import numba as nb
  from concurrent.futures import ThreadPoolExecutor
  from multiprocessing import cpu_count

  @nb.jit(nogil=True)
  def slow_calculation(x):
      out = 0
      for i in range(x):
          out += i**0.01
      return out

  ex = ThreadPoolExecutor(max_workers=cpu_count())
  futures = [ex.submit(slow_calculation, 100_000_000_000+i) for i in range(cpu_count())]