It's not a big deal for the first world, but poorer nations may hold out for future vaccines that remain stable at higher temperatures and only require a single dose.
Merck is working on a one-dose pill, but that's not expected before mid-2021.
There's micro encapsulation for vaccines.[1][2] The vulnerable active molecule can be put inside a coating that is stable in storage but dissolves after injection.
[1] https://www.academia.edu/33376119/Microencapsulation_of_Vacc...
[2] https://www.sciencedirect.com/topics/immunology-and-microbio...
Valid point, but I feel there's never been a better time for massively pushing this vaccine (after proper testing and regulatory approval, of course) to medium/low income countries.
Winter should make it much easier in managing the temperature range stability required for storing/shipping the vaccine, especially in countries around the equatorial region.
Doing it in late spring/summer will not be a good idea (assuming a better vaccine doesn't come out by then).
That's a big issue. The N95 mask shortage demonstrates that the US manufacturing industry has far less surge capacity for simple items than previously thought.
The SF bay area has dry ice delivery.[1] Lagos, Nigeria has dry ice delivery.[2] Bismark, North Dakota has a dry ice plant.[3] It's not hard to get.
Coolers for holding items in dry ice are about $100 on Alibaba.[4]
This doesn't look like a big problem.
[1] https://bensdryice.com/
[2] https://www.businesslist.com.ng/company/256889/greatsmith-re...
[3] http://www.dryiceweb.com/Praxair/Bismarck_ND.htm
[4] https://www.alibaba.com/product-detail/Vaccine-Carrier-Biome...