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Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by hedora on Monday November 09, 2020 @11:20AM (#25036327)
Also bad:

What did they use to stabilize the mRNA?

If they’re managing to do it with just temperature and maybe glycerol, that’s great.

If it’s RNAlater, then that’s going to have safety issues. If it’s something else, how was the additive tested for long term safety? (Vaccines like this have been in the works for a long time. There has been time for safety studies.)

Edit: RNAlater MSDS sheet: https://tools.thermofisher.com/content/sfs/msds/2012/AM7020_...

Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by hundchenkatze on Monday November 09, 2020 @03:43PM (#25039636)
I don't read safety sheets often so I'm likely off base here, so please correct me if I'm wrong. My interpretation is that when used correctly it's safe.

Section 2 states it is non-hazardous.

Section 4 states it is not expected to present a significant ingestion/inhalation hazard under anticipated conditions of normal use.

Finally, Section 11 indicates that the Ammonium compounds present in RNALater may be harmful, but only when they are administered at LD50 concentrations.

Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by JohnJamesRambo on Monday November 09, 2020 @11:25AM (#25036394)
What is wrong with RNAlater? Seems like it is just EDTA and Sodium Citrate and Ammonium Sulfate.

https://www.protocols.io/view/RNAlater-Recipe-c56y9d