"...will that money make you happy?"

Yes. Very. More than you can imagine. Trading good work for great sums of money isn't selling your soul. No one is under a moral obligation to build something that benefits the future of humanity. Furthermore, the vast majority of startups (including the 3 mentioned) were arguably never going to be humanity-changing businesses regardless.

If this is a conversation worth having at least reference bio-science and space exploration startups that actually have a chance to change the world.