Re:How the Coronavirus Hacks the Immune System
by nextos on Monday November 02, 2020 @09:10PM
(#24975681)
Yes, and if you have different versions of the HLA gene, you get different distributions as a result of V(D)J recombination.
So, in a way, different individuals have different immune strategies. For example, super-responders to HIV tend to be HLA-B57. This HLA "version" trades better response to virus that mutate quickly for more chances of autoimmunity as thymic selection is less stringent (because HLA-B57 presents less selfpeptides in the thymus).
So, in a way, different individuals have different immune strategies. For example, super-responders to HIV tend to be HLA-B57. This HLA "version" trades better response to virus that mutate quickly for more chances of autoimmunity as thymic selection is less stringent (because HLA-B57 presents less selfpeptides in the thymus).