The main thing isthat it doesn't support system calls, so the vast majority of code won't run. The ability to translate from one architecture to another is super cool though, and if you're curious about it you should check out McSema/Remill:

https://github.com/lifting-bits/mcsema

https://github.com/lifting-bits/remill

https://blog.trailofbits.com/2018/01/23/heavy-lifting-with-m...