I had a colonoscopy almost two weeks ago (a 3-year follow-up on having a large not-quite-cancerous-yet polyp removed), and got in a lot of Factorio the night before.

So in a sense it wasn't that different than a regular night of staying up till four in the morning playing Factorio, except that I had to drink a gallon of stuff that tastes like diluted seawater. I had forgotten how gross that stuff is, but in the end that was the worst part.