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Re:Show HN: SmartGuitarAmp – Guitar plugin made with deep le... by hannasanarion on Saturday October 10, 2020 @08:42PM (#24743007)
For purpose-made hardware, basically never.

If you're doing all of the emulation and signal processing on a general-purpose computer, then sure, you often run into latency problems, and part of the set up process for those software tools is latency calibration. The one that I use when at my desktop, Guitarix, is very conservative with its latency, defaulting to like 500 milliseconds, I turn it down to 20-30 or so and it still functions on my hardware and you can't tell the difference: it's the same time delay as playing through a speaker 20 feet away.

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