Cell rejected an almost-nobel-worthy paper? Is this business as usual? Would they maybe have got the nobel price, if they had submitted to a lesser journal instead of Cell?

Can we make a rule of thumb, that in general you should submit your groundbreaking work to the most prestigious journal possible, but if you feel your work is of nobel caliber, then play it safe and submit to a mediocre journal to avoid the high publication threshold of the top level journals?