I don't mind it that much for programming languages like Python. The one annoyance I have is related to editor tooling: In languages that use braces to denote blocks, I can paste a block of code wherever and have my editor autoformat it to the correct indentation level, while in Python I have to be more deliberate with increasing or decreasing the indentation of a pasted snippet, and sometimes I'll make a mistake in the process that isn't caught until later.

I dislike significant indentation for configuration because the nesting tends to get deeper than for programming languages and it can be harder to see what's going on.