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Re:Raspberry Pi – UASP, Trim, and Boot Performance via USB by rwmj on Sunday September 20, 2020 @09:06AM (#24533788)
I wouldn't trust any of those USB sticks for anything other than very light, mostly read-only use. However the SSD and NVME drives are likely to be a lot more reliable - since they are just desktop NVME/SSDs in a shell that converts the interface to USB 3 they are as reliable as an NVME/SSD in a desktop or laptop.

Be aware (as I found out a couple of days ago) the RPi 4 USB port cannot power an external USB hard disk unless you use a separate powered hub. Should be fine to use a USB SSD / USB NVME though.

Re:Raspberry Pi – UASP, Trim, and Boot Performance via USB by kingosticks on Sunday September 20, 2020 @12:26PM (#24534918)
I've been using an external portable (2.5") seagate drive[0] for a while with my pi 4 to hold music and videos. It's plugged straight into the USB 3 port with no problems so far.

You will have problems trying to power a desktop 3.5" drive though.

[0] https://www.amazon.co.uk/Seagate-Expansion-Portable-PlayStat...