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A comment on AstraZeneca Covid-19 vaccine study put on hold due to suspected adverse reaction. Parent comment

Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by mrfusion on Tuesday September 08, 2020 @06:43PM (#24414470)
Do the adenos actually have to infect the cells to produce the spikes?
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Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by dogma1138 on Tuesday September 08, 2020 @07:03PM (#24414658)
Yes, they don’t replicate virons that could be assembled the virus was modified to mainly replicate the spike proteins since your cells send samples of anything they replicate to the cell wall for your immune system to monitor and sample this is how the adaptive immune response is achieved.
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Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by nextos on Tuesday September 08, 2020 @08:06PM (#24415147)
> Wow nature is truly a marvel! How do they do that? Or where could I read more?

Read about the HLA/MHC class I pathway. And also about JAK/STAT1, which is how cells decide if they are infected.

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Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by im3w1l on Tuesday September 08, 2020 @08:01PM (#24415092)
> cells send samples of anything they replicate to the cell wall for your immune system to monitor

Wow nature is truly a marvel! How do they do that? Or where could I read more?

[ Parent | on HN ]
Re:AstraZeneca Covid-19 vaccine study put on hold due to sus... by kurthr on Tuesday September 08, 2020 @07:21PM (#24414821)
Exactly, for strong long term response you want T-cell involvement.
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