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A comment on Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers. Parent comment

Re:Low Doses of LSD Acutely Increase BDNF Blood Plasma Level... by evo_9 on Sunday September 06, 2020 @03:07PM (#24393799)
I don't disagree with this; I do wonder however if this is more related to the black-market nature of this drug. Aka, inconsistent 'manufacturing' processes, etc. Meaning if it were legal and had a process in place to assure the correct chemical composition, if that would still happen.

Thinking about this further - have bad trips been observed in clinical studies where the the LSD was created in a controlled, ideal lab setting?

Would be interesting to know if this was or wasn't the case; could indicate a bad trip is an unavoidable potential side-effect, or if it is a specific reaction to poorly created LSD.

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Re:Low Doses of LSD Acutely Increase BDNF Blood Plasma Level... by saiya-jin on Sunday September 06, 2020 @03:50PM (#24394129)
I've seen really bad trips from literally just weed, the same I smoked and was as A-OK as possible. I mean really bad stuff, like blood flowing down the walls around us, they are coming for us panick etc.

Its not the substance purity, but some people are a mess, and sometimes they don't realize/admit it. Some become mess with frequent use. Those definitely shouldn't play with stronger stuff, whatever that is for them.

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Re:Low Doses of LSD Acutely Increase BDNF Blood Plasma Level... by Enginerrrd on Tuesday September 08, 2020 @11:18AM (#24409256)
>Meaning if it were legal and had a process in place to assure the correct chemical composition, if that would still happen.

It will. I'll stake my life-savings on it too.

>Thinking about this further - have bad trips been observed in clinical studies where the the LSD was created in a controlled, ideal lab setting?

Yes, actually, the results here are the ones usually criticized by psychonauts for causing bad trips due to "bad settings" or "poor preparation". There's a bit of truth to that, but the bad trips are always going to happen.

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