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Re:Supercomputer analysis of Covid-19 leads to new theory by hellofunk on Wednesday September 02, 2020 @11:36AM (#24354230)
> Interestingly, Jacobson’s team also suggests vitamin D as a potentially useful Covid-19 drug. The vitamin is involved in the RAS system and could prove helpful by reducing levels of another compound, known as REN. Again, this could stop potentially deadly bradykinin storms from forming. The researchers note that vitamin D has already been shown to help those with Covid-19. The vitamin is readily available over the counter, and around 20% of the population is deficient. If indeed the vitamin proves effective at reducing the severity of bradykinin storms, it could be an easy, relatively safe way to reduce the severity of the virus.
Re:Supercomputer analysis of Covid-19 leads to new theory by shubhamjain on Wednesday September 02, 2020 @11:47AM (#24354350)
This Medium article was written on March 10 [1].

"Put simply, medics found that severely ill flu patients nursed outdoors recovered better than those treated indoors. A combination of fresh air and sunlight seems to have prevented deaths among patients; and infections among medical staff.[1] There is scientific support for this. Research shows that outdoor air is a natural disinfectant. Fresh air can kill the flu virus and other harmful germs. Equally, sunlight is germicidal and there is now evidence it can kill the flu virus."

[1]: https://medium.com/@ra.hobday/coronavirus-and-the-sun-a-less...

Re:Supercomputer analysis of Covid-19 leads to new theory by kovek on Wednesday September 02, 2020 @12:04PM (#24354538)
That air is a natural disinfectant is super interesting.

I read that vitamin D and observed benefits for those who have vitamin D is a correlation. Meaning that taking vitamin D supplements might not be as helpful as getting sunlight (a natural way to get vitamin D)

Re:Supercomputer analysis of Covid-19 leads to new theory by jmvoodoo on Wednesday September 02, 2020 @12:42PM (#24355006)
What I found interesting about this article is that it isn't based on a correlation of outcomes and vitamin D like most other results are. It's actually looking at potential mechanisms and vitamin D is coming up as a candidate.
Re:Supercomputer analysis of Covid-19 leads to new theory by mcguire on Wednesday September 02, 2020 @01:16PM (#24355402)
I don't know about air, but ultraviolet light is a pretty good disinfectant.
Re:Supercomputer analysis of Covid-19 leads to new theory by wirrbel on Thursday September 03, 2020 @01:48AM (#24361100)
but patients don't disinfect from the inside when exposed to outdoor air...
Re:Supercomputer analysis of Covid-19 leads to new theory by trhway on Wednesday September 02, 2020 @01:35PM (#24355627)
ozone too. And it goes inside your nose, throat, lungs.
Re:Supercomputer analysis of Covid-19 leads to new theory by robbyt on Thursday September 03, 2020 @01:16AM (#24360978)
I'm still waiting for the results from that whole bleach in the lungs idea Trump had. Hoping that will be the cure for all of this.
Re:Supercomputer analysis of Covid-19 leads to new theory by wirrbel on Thursday September 03, 2020 @01:50AM (#24361109)
UV radiation is the disinfectant. Also the vast amount of air makes a dillution of germs and aerosols more likely which is great.

With regards to sunlight exposure, sunbathing in the alps was a go-to tuberculosis treatment prior to having antibiotics.

Re:Supercomputer analysis of Covid-19 leads to new theory by pmiller2 on Wednesday September 02, 2020 @01:42PM (#24355701)
I would guess "air as disinfectant" is primarily because of its oxygen content. O_2 is actually a pretty nasty molecule like that. Oxidation is typically a fairly tough reaction to reverse or prevent.
Re:Supercomputer analysis of Covid-19 leads to new theory by SomeAmerican on Wednesday September 02, 2020 @03:23PM (#24356897)
Isn't there plenty of O_2 indoors also?
Re:Supercomputer analysis of Covid-19 leads to new theory by throwaway_pdp09 on Wednesday September 02, 2020 @04:20PM (#24357672)
Ozone is 03 (https://en.wikipedia.org/wiki/Ozone). 02 is the normal oxygen as we think of it.
Re:Supercomputer analysis of Covid-19 leads to new theory by m0zg on Wednesday September 02, 2020 @06:13PM (#24358818)
Maybe it's not even a "disinfectant". It's just that you aren't re-breathing stale air with droplets in it, when outside. Assuming, of course, you aren't wearing a mask. :-)
Re:Supercomputer analysis of Covid-19 leads to new theory by raverbashing on Wednesday September 02, 2020 @11:53AM (#24354420)
Yes but can it kill viruses and bacteria in vivo?
Re:Supercomputer analysis of Covid-19 leads to new theory by nradov on Wednesday September 02, 2020 @12:33PM (#24354895)
Aytu BioScience is working on an ultraviolet device to kill viruses in vivo. Initial results look promising but it's too early to say whether that would be an effective therapy.

https://aytubio.com/healight/

Re:Supercomputer analysis of Covid-19 leads to new theory by Nuzzerino on Wednesday September 02, 2020 @01:28PM (#24355544)
This one was also infamously censored by social media this year.
Re:Supercomputer analysis of Covid-19 leads to new theory by WhompingWindows on Wednesday September 02, 2020 @02:14PM (#24356045)
By "it" what are you referring to?

Vitamin D may have modulatory effects on the biochemical pathways linked in the original article. Most pharmaceutical products we study aren't going to directly kill bacteria or viruses, usually they have a particular physical effect on a specific molecule that then leads, through various cellular pathways, to the death or suppression of the pathogen. I highly doubt Vitamin D directly kills anything, it could modulate symptoms or the pathophysiology of COVID-19 the disease, vs. SARS-COV-2 the virus itself.

If "it" means UV light, yes there are UV sterilizers aplenty today. If "it" means outdoors/fresh air, there are a lot of components to that and it's not like "fresh air" enters "in vivo" per se.

Re:Supercomputer analysis of Covid-19 leads to new theory by raverbashing on Wednesday September 02, 2020 @04:19PM (#24357650)
I mean UV light/being outdoors

Yes, I'm aware of UV sterilizer, but does it work when the microorganisms are inside you? You don't want to get an "internal tan"

Re:Supercomputer analysis of Covid-19 leads to new theory by Enginerrrd on Wednesday September 02, 2020 @12:12PM (#24354616)
If it produces better outcomes in vivo, does it matter whether or not the proposed mechanism is correct?
Re:Supercomputer analysis of Covid-19 leads to new theory by gh02t on Wednesday September 02, 2020 @12:44PM (#24355031)
Ideally you'd like to understand the mechanism so that you can isolate and optimize the the effect, as well as predict possible interactions/side effects.
Re:Supercomputer analysis of Covid-19 leads to new theory by HeadsUpHigh on Wednesday September 02, 2020 @02:26PM (#24356186)
Ideally. In reality it rarely happens. And it's certainly not needed, the entire basis upon which evidence-based medicine is founded is that an effective intervention should be statistically measurable in it's effect regardless of our knowledge of the underlying mechanics.
Re:Supercomputer analysis of Covid-19 leads to new theory by nradov on Wednesday September 02, 2020 @11:47AM (#24354348)
See Dr. Gerry Schwalfenberg's letter on the "Vitamin D hammer" for treating respiratory viruses. While not a controlled study it does point toward an avenue for further research.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463890/

Re:Supercomputer analysis of Covid-19 leads to new theory by iscrewyou on Wednesday September 02, 2020 @01:06PM (#24355264)
This is discussed in this radio lab episode as well: https://www.wnycstudios.org/podcasts/radiolab/articles/invis...

Very very interesting theories as it also helped during the 1918 flu.

Re:Supercomputer analysis of Covid-19 leads to new theory by hinkley on Wednesday September 02, 2020 @03:08PM (#24356690)
Is it my imagination or are the successes mostly coming from controlling inflammation responses?