Re:Antibiotics nearly double risk of developing IBD, doctors...
by vharuck on Thursday August 27, 2020 @04:20PM
(#24298182)
My guess is the control group wasn't made of people with no history of antibiotics. They just used the model to predict the risk difference between zero and one time of taking antibiotics. The control was people from the general population, and the "test" was people who had already developed IBD.
Though there are people, like me, who are allergic to many common antibiotics. Between some bad reactions in childhood and an emergency three years ago (over two decades), I never had antibiotics.
Re:Antibiotics nearly double risk of developing IBD, doctors...
by refurb on Thursday August 27, 2020 @07:08PM
(#24299689)
Taking another look, I think they are measuring antibiotic dispensations within the time period. Which makes a ton more sense because I'm imaging the number of people who have never been exposed to an antibiotic over their entire lifetime is pretty small.
- I'm surprised they could find controls who had never received antibiotics. I assume this over some time period and not lifetime
- For each exposure to antibiotics, there was a stepwise increase in risk from 1.11 to 1.38 to 1.55
- When they matched them to siblings, the risk went down (1.35 versus 1.88) suggesting a genetic component to the overall risk