IIRC malaria in africa is basically totally resistant to HCQ by now. There's places where resistance to Artemisinin is a thing.
It’s called the advancement of science and it’s one of the reasons it is not generally a frontline treatment (because we have more effective treatments now, as well as resistance).
You might as well say that a person is too phlegmatic and needs bleeding when they have gallstones.
The world moves, move with it
That or finding ways to sterilize all anopheles mosquitoes, or do other mosquitoes carry it also