On the boards it has been ported to, I2C and SPI are directly supported (https://docs.micropython.org/en/latest/library/machine.SPI.h...). No C coding necessary. It's not a replacement for C on every embedded application, but for prototyping and one-off applications it's hard to beat the productivity gains. It will run on an ESP8266-01 module for as low as $2 ea.