I think that in general you CAN learn and skip those holes if you have someone to guide you that already knows the subject well.

But as a person who may be really new to the subject of development and computer science I think it's obvious that without a lot of research and prep ahead of time you might start with a book or topic and keep moving forward, but you may not be exposed to all of the same things (some probably really useful, some are likely bullshit) that you'd get in a more structured learning environment.