Re:New insights into “bradykinin storms” suggest potential t...
by sradman on Tuesday August 04, 2020 @09:48AM
(#24049894)
The original paper A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm [1]:
> ...our results indicate that the pathology of COVID-19 is likely the result of Bradykinin Storms rather than cytokine storms (although given the induction of IL2 by BK, the two may be intricately linked).
> Several interventional points (most of them already FDA-approved pharmaceuticals) could be explored with the goal of increasing ACE, decreasing BK, or blocking BK2 receptors (Table 1).
> ...our results indicate that the pathology of COVID-19 is likely the result of Bradykinin Storms rather than cytokine storms (although given the induction of IL2 by BK, the two may be intricately linked).
> Several interventional points (most of them already FDA-approved pharmaceuticals) could be explored with the goal of increasing ACE, decreasing BK, or blocking BK2 receptors (Table 1).
[1] https://elifesciences.org/articles/59177