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Re:AstraZeneca exempt from coronavirus vaccine liability cla... by refurb on Saturday August 01, 2020 @08:10PM (#24025115)
That's not happening, what will be accelerated will be regulatory approvals and reviews, not clinical trials.

The trials are most certainly accelerated. Take a look at Moderna's trial of their RNA vaccine.[1]

It's a 2 year trial, but data is collected on a rolling basis. They aren't waiting 2 years for final results, I'm guessing they do a few interim analyses until they see the two arms split in terms of infection rate. Then they'll go to the FDA and see if that's sufficient for approval.

And look at the N-size. 30,000 people for a drug that will be given (potentially) to billions of people. To make a comparison, Gardasil, the HPV vaccine was tested in ~28,000 individuals over 3-4 years.[2] And Gardasil is used in a much more limited population than the Covid vaccine will be.

[1]https://clinicaltrials.gov/ct2/show/NCT04470427?term=mRNA-12... [2]https://www.fda.gov/files/vaccines,%20blood%20&%20biologics/...

Re:AstraZeneca exempt from coronavirus vaccine liability cla... by baryphonic on Sunday August 02, 2020 @12:04AM (#24026237)
> And Gardasil is used in a much more limited population than the Covid vaccine will be.

(It wouldn't be HN without a splash of pedantry; apologies in advance.)

I'm curious what you mean by this. Women constitute slightly more than half of the population, no? There are probably billions of women at this point who have had Gardisil administered.

Re:AstraZeneca exempt from coronavirus vaccine liability cla... by Marsymars on Sunday August 02, 2020 @12:31AM (#24026348)
270 million doses worldwide to date, of those 100 million are in the USA. The full course is two or three doses depending on age, so that's somewhere between 90-135 million people fully covered.

https://www.cancer.org/cancer/cancer-causes/infectious-agent...

And it's not limited to women now. Different countries have it approved/covered for men of different ages. I (as a man) recently finished the full course, though I had to pay for it out of pocket.

Re:AstraZeneca exempt from coronavirus vaccine liability cla... by refurb on Sunday August 02, 2020 @12:20AM (#24026302)
That's a fair question!

So Gardasil is only approved for "girls and women 9 through 26 years of age". Plus there wasn't much expectation of use outside of Western countries initially since it's not cheap and there are likely higher priority vaccines in developing countries (i.e. do you spend dollars on this or meningitis vaccines?). Use is probably pretty broad now, ~10 years post-launch.

Eventually they expanded the label to include "boys and men 9 through 26 years of age".

So all in all, a relatively small slice of the population, where for the Covid vaccine, they're trying to get it approved for pretty much everybody.

Re:AstraZeneca exempt from coronavirus vaccine liability cla... by baryphonic on Monday August 03, 2020 @03:28PM (#24042217)
Oh, great point. I hadn't even thought about the fact that certain vaccines are approved only for certain age ranges.
Re:AstraZeneca exempt from coronavirus vaccine liability cla... by sokoloff on Sunday August 02, 2020 @12:15AM (#24026277)
HPV vaccination is now recommended for all adolescents.
Re:AstraZeneca exempt from coronavirus vaccine liability cla... by travmatt on Sunday August 02, 2020 @01:04AM (#24026499)
Michael Douglas died from throat cancer contracted from HPV, as undoubtedly other men have. There’s reason for men to become vaccinated as well.
Re:AstraZeneca exempt from coronavirus vaccine liability cla... by Blackthorn on Sunday August 02, 2020 @02:12AM (#24026725)
Michael Douglas is still very much alive, but it's still a good point that men should get vaccinated.
Re:AstraZeneca exempt from coronavirus vaccine liability cla... by travmatt on Sunday August 02, 2020 @12:23PM (#24029593)
I don’t know why I thought he passed for. But yea, hpv can lead to cancer in both genders.