Glucosamine Supplementation Reduces All-Cause Mortality: Study

Re:Glucosamine Supplementation Reduces All-Cause Mortality: ... by hkt on Friday July 31, 2020 @06:40PM (#24015075)

Is a Cochrane review really a primary source? They're meta-analysis, which I'd think of as secondary.

In the case linked, the analysis seems pretty unequivocally to not support supplementing:

"We found no evidence to support antioxidant supplements for primary or secondary prevention. Beta-carotene and vitamin E seem to increase mortality, and so may higher doses of vitamin A. Antioxidant supplements need to be considered as medicinal products and should undergo sufficient evaluation before marketing."

Did I miss something?

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Re:Glucosamine Supplementation Reduces All-Cause Mortality: ... by JamesBarney on Friday July 31, 2020 @07:13PM (#24015411)

The op talks about sulforaphane but then links to an article about vitamin a and e(I don't know why) They're totally different chemicals that work through completely different pathways.

And a study on vitamin a and e etc doesn't tell you much about other supplements. Just like how a study on does whether or not statins are associated with reduced mortality tells you little about whether or not ACE inhibitors are associated with reduced mortality.

Also I don't think op meant primary source as in primary vs secondary sources but meant in the sense of "this doctor primarily uses Cochrane as his source for information"

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Re:Glucosamine Supplementation Reduces All-Cause Mortality: ... by DiabloD3 on Friday July 31, 2020 @07:02PM (#24015301)

Vitamin E research also ends up being a bit YMMV: most commercially available Vitamin E is one form only, alpha tocopherol... except Vit E is 8 different forms: 4 tocopherols and 4 tocotrienols.

The research that has been done so far basically indicates alpha tocopherol-only supplementation aligns identically with unspecified-Vitamin-E-is-bad research.

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