The only time I have taken karma in to consideration is when I disagree with someone either in principle or in technical merit. If I were to even respond to such a post, I want to know if I am dealing with a troll or someone who is a highly regarded member of the community because they have earned their karma. Basically, I let it influence how I might approach someone to a certain extent. Other than that, I could care less what my or anyone else's karma is.