In people who are not seeking estradiol treatment for body dysphoria, prescribing estradiol can still be a viable treatment for issues other than body dysphoria where, due to genetic or other issues, raising their circulating estradiol (E2) blood levels results in a medically positive outcome. In one paper on this topic, two such medical conditions are hypogonadism and prostate cancer:

https://eje.bioscientifica.com/downloadpdf/journals/eje/181/...