I only have one card. I swapped the Titan V with my 1x1080 in my old, cheap motherboard and it just worked. I had to hook up the water cooling, but I did that because it came with a block, not because I optimized the thermal design. To verify motherboard compatibility, I looked up in the nvidia specs how many PCIe lanes and at what speed I should expect and confirmed in HWinfo that they were active in that configuration -- much like I'd look at a network interface to make sure my 10/5/2.5GbE hadn't turned into 1GbE on account of gremlins in the wires.

I'm not using this for machine learning, so you might want to talk to someone who is before pulling the trigger. In particular, my need for fp64 made the choice of Titan V completely trivial, whereas in ML you might have to engage brain cells to pick a card or make a wait/buy determination.