I suppose TLoU2 stands out because of it's rather 'serious' story, its unusually graphic violence (and attempts to humanize the NPC's more), and of course the blockbuster nature of it.

Furthermore, I've always found the Naughty Dog core gameplay (in Uncharted as well as TLoU) surprisingly boring and somehow disconnected from the narrative. Good enough to make it more than just an interactive movie, but only passably so.