I watched a great talk about this, and how to avoid problems that result from it. The presenter built a framework that made random changes to alignment of various blocks of code with two different versions of the same microbenchmark until it had high statistical confidence that either one was faster than the other, or it would eject and say that the difference between the two was statistically insignificant. Or something along those lines.

I'm looking for the video now, but I can't find it. Pretty sure it was CppCon but I'm not positive.