I don't think active applications are innovative or quirky. But I do think that they are effective (when done right) and I hope they have staying power. The resume is long overdue for a bit of reinvention. But you are absolutely right: the site must present work tailored very specifically to the company you are chasing. It has to do more than mention them by name. My biggest critique is that I think she should have put some of the effort into a proposed redesign of an instagram feature. Some piece of work that would help them imagine her contributions as an employee.
I certainly wouldn't vote this stuff up, but no need to be rude about it.
(Edit: also, why keep downvoting him, I think he probably gets the idea already)
"Be civil. Don't say things you wouldn't say in a face to face conversation. "
It's a pretty good rule for writing things on line whether it's in the guidelines or not. Sometimes you (meaning: all of us) get tempted to be snide or snarky, but if you think that there's another person out there, and if you pretend you're saying whatever you have to say to them directly, I find that it greatly improves what you write.
It doesn't mean "don't criticize", just do it as if that person were in front of you.
EDIT: After looking through the whole thing, I have to revise my opinion. It doesn't even qualify as mediocre -- copy and design are surprisingly awful. Large quantities of pseudo-charming nonsense ("I'm vehement about creating kick-ass interactions", "i can write a mean agile spec, and i’m comfortable working in a highly iterative environment", the complete section outlining why she's supposedly great for the gig) and completely interchangeable self-promotion. Active applications can be interesting if they're actually tailored to the company in question; this particular instance can't be bothered to make any meaningful connection to Instagram. Well, except for the domain name.