For some context, the most profitable company in the world in 2010 was Gazprom[1], the largest exporter of natural gas in the world, with 24,555.7 million.
EDIT: Gazprom was the most profitable in 2009, not 2010, as pointed out below.
[1] http://www.businessinsider.com/dropbox-revenue-2011-3
[2] http://money.cnn.com/magazines/fortune/global500/2010/perfor...
Exxon did $30B profit in 2010. - http://www.google.com/finance?q=NYSE:XOM&fstype=ii
Exxon did $30B profit on $375B revenues. Net profit margins of less than 10%.
Of course we won't know until Dropbox releases their financials, but I strongly believe that they will be a bombshell when they are released. Nothing like anything we have ever witnessed.
I would not be surprised if their Net Profit margins are 30% - 50%.
At those rates, all it takes is for them to be doing revenues of $100B to exceed Exxon's profit take in 2010.
I know it seems a bit far fetched now, but so did every other technology giant when they were in the budding phases.
I think it would be foolhardy to bet against them.
E.g. I have a dropbox account at home, and had one for work. So did my boss, and some other coworkers.
So while there are 2 billion internet users, there are many organiztions - profit, non-profit, ngo, etc - which makes the pie even bigger.
Predicting it will be the most profitable company in the world sounds absurd to me. But that's just me.