This is a non issue to me. I don't use apps half way across 2 screens. Its just a minor bit of weirdness while dragging them.
I'm running a couple medium high density monitors alongside one of the highest density ones available. I don't scale the HIDPI monitor at all, which means when I drag windows to it they are tiny. Instead it works in two ways, as a status screen for activity monitors/etc and as a text/document editing screen. AKA putting adobe acrobat, firefox or sublime/emacs/etc on the high DPI screen and then zooming in gives all the font smoothing/etc advantages of high DPI without needing OS support.
So the TLDR is, turn off dpi scaling, and leave the hidpi screen as a dedicated text editor/etc with the font sizes bumped to a comfortable size. Bonus here is that the additional effort of clicking the menu/etc will encourage learning keyboard shortcuts.
What is really tricky, though, it's having two monitors with different DPI. Win 10 does an acceptable job with it; no Linux tools I'm aware of can handle it reasonably well. Some xrandr incantations can offer partial solutions.