Browser support is very good: https://caniuse.com/#feat=cryptography
Documentation is also very good: https://developer.mozilla.org/en-US/docs/Web/API/SubtleCrypt...
In terms of "ease of misuse" it's debatable. One of the biggest default security improvements with Web Crypto is that *cryption keys are _not readable by JS_ once instantiated - they can only be used by the cryptographic functions (unless you explicitly make them exportable). This is a subtle but very important defense against certain drive-by attacks that could dump loaded keys from whatever non-native JS crypto library you might be using.
In general I don't think it's safe to be using crypto at all outside of basic stuff like password hashing if you don't have a basic understanding of concepts like salt lengths, block cipher modes, hasher output sizes, etc. so I don't really agree with the "easier to misuse" statement. Some library that holds your hand more isn't going to significantly make things safer.
In terms of it being easy to misuse, I think that applies to cryptography in general, but there are some gotchas lingering in javascript.
Self blog promoting. I just put this out a few days ago on this very subject. https://pritact.com/blog/posts/crypto-mistakes-part-1.html
That's a really nice feature. This should be better advertised. I wasn't aware that Web Crypto was even a thing.