Interesting. Do you mean playing a specific game or just using VR in general?

Not any specific game, but some have character motion that isn't strictly coupled to player motion (e.g. performed by a controller like conventional first-person games), and I found that very unpleasant at first. Gradually I got used to this disconnected motion; the only thing that still made me queasy was disconnected rotation, but that is rare (moving platforms in Doom 3 are the only example I remember).

I used to suffer motion sickness as a passenger in cars, sometimes buses, and ships, but at least the first two went away along with the ‘VR sickness’. (I haven't been on a ship since.)