CPython, the reference implementation, interprets Python. PyPy interprets and JIT compiles Python, and more exotic things like Cython and Grumpy statically compiles Python (often through another, intermediate language like C or Go).

Node.js, using V8, interprets and JIT compiles JavaScript.

Although note that, while Node.js is fast relative to Python, it's still pretty slow. If you're writing web-stuff, I'd recommend Go instead for casually written, good performance.