> With Chrome taking the lion's share of the browser user market, you end up with a lot of sites that work well in Chrome but not so well with other browsers.

TBH the only sites where I have noticed this are Google sites like Hangouts and YouTube. But even those work fine, they just seem to use quite a lot more CPU than I think they should. I do have Chrome as a backup in case something doesn't work, but I can't remember the last time I had to use that.