Depends on how much energy you need. If you are talking about turning it into an interstellar spacecraft by hooking up some kind of fusion powered thruster (probably using H2 as the reaction mass) to the back you may need all of its mass.

This is of course well beyond our current capabilities, but it's not something that's impossible to consider in the medium-distant future. Plus, even if you expend a colossal amount of energy accelerating you're still talking about thousands of years for the journey where you'll need to keep those reactors running for the entire trip (there is no useful solar collection in deep space) having a literal mountain of fuel to start with is important.