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A comment on After 100K Covid-19 cases, it’s clearer where Californians are getting infected. Parent comment

Re:After 100K Covid-19 cases, it’s clearer where Californian... by hcknwscommenter on Sunday May 31, 2020 @02:21AM (#23367644)
You are dangerously misinformed. RNA polymerase requires Zinc. In fact, I believe essentially all polymerases known use Zinc as a core component of their catalytic chemistry.
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Re:After 100K Covid-19 cases, it’s clearer where Californian... by pdonis on Sunday May 31, 2020 @03:10AM (#23367822)
> You are dangerously misinformed.

No, you are:

https://jvi.asm.org/content/91/21/e00754-17

Paper title: "Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase"

Published in 2017.

https://pubmed.ncbi.nlm.nih.gov/21079686/

Paper title: "Zn(2+) Inhibits Coronavirus and Arterivirus RNA Polymerase Activity in Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture"

Published in 2010.

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Re:After 100K Covid-19 cases, it’s clearer where Californian... by dekhn on Sunday May 31, 2020 @10:56AM (#23369952)
The person you replied to is technically correct: DNA-dependent RNA polymerases are zinc metalloenzymes, have zinc at the active site, and the zinc is required for catalytic functionality.
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