I've had luck with using the approach in here https://nixos.wiki/wiki/Python#Emulating_virtualenv_with_nix... because it allows the escape hatch of using pip if something isn't packaged and I want to quickly try something out. I have also been meaning to try mach-nix which may obviate the need for pip at all. Having a good standard skeleton for a python/nix project would be super helpful to add to the wiki, etc.