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Re:State of Emacs Lisp on Guile by jpfr on Monday May 18, 2020 @07:19AM (#23220984)
Unfortunately, this comparison uses Guile 2.2. Guile 3 is out and has greatly improved the performance via Wingo‘s JIT.

AFAIK the biggest point that brought Guile-Emacs to a standstill is the internal string representation of Emacs that is different from Guile’s native format.

Re:State of Emacs Lisp on Guile by bjoli on Tuesday May 19, 2020 @08:15AM (#23233978)
I am not sure that would help. Guile elisp is slow. I don't think there is anything stopping it from being as fast as guile sche, except for maybe man-hours.
Re:State of Emacs Lisp on Guile by jcalve on Tuesday May 19, 2020 @06:05AM (#23233165)
The author updated the post with benchmarks for Guile 3.