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Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by jrockway on Monday May 11, 2020 @04:26PM (#23146601)
I guess we need to know the total number of cases to figure out what the deaths mean, and until everyone has gotten an antibody test, we can't know that total number.

To make the numbers work for the "weird cold" in early February case, I guess we have to work backwards. Assume that when we went into lockdown was the actual peak, 8 million people in New York City had COVID-19. That means that there is one death for every 500 cases. Then we have to pick a reproduction rate, which I have no idea how to pick, so I'll say that it increases by 1.5x every day (so on day one you have x cases, then on day 2 you have x + 1.5x, then on day 3 you have x + 1.5x + (1.5)^2x, etc. Going back a month from March 20 (which is approximately 30 days, and when a lot of people report their "weird cold"), that would mean we'd expect around 8 million / 383500 = 20 cases on Feb. 20. With 1 death per 500 cases, you'd have 0 deaths at that level.

I know I've pulled these numbers out of my nether region and so they are likely very wrong. But with some back-of-the-envelope math, I think we can have some sick people in February without a lot of deaths.

Obviously my 8 million total cases in NYC number is too high, and the 20 cases on 2/20 is too low for me and my friends to be those cases. But that exponential can be tweaked to make something plausible. If we make it 1.2 instead of 1.5, then we should have had about 7000 cases on 2/20, and that means around 14 deaths. That seems quite plausible to me. So I dunno. There was a weird cold. It's weird. It could mean anything.

I signed up to get an antibody test. 1 test is not data, but it will be very interesting to see the results.

Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by Izkata on Tuesday May 12, 2020 @10:49PM (#23162930)
> Then we have to pick a reproduction rate, which I have no idea how to pick, so I'll say that it increases by 1.5x every day (so on day one you have x cases, then on day 2 you have x + 1.5x, then on day 3 you have x + 1.5x + (1.5)^2x, etc

> I know I've pulled these numbers out of my nether region and so they are likely very wrong. But with some back-of-the-envelope math, I think we can have some sick people in February without a lot of deaths.

Yeah, in two ways: That's not how the growth rate math works, but if we went by your math instead of the number, that's about 4-5x faster than what we were seeing in March.

A growth rate of 1.5 means if we had X cases on day 1, we'd have X(1.5^1) on day 2, and X(1.5^2) on day 3. This virus's growth rate at the beginning of the pandemic stage was around 1.4 (or to use your math, 0.4? I'm not sure what you meant by "(1.5)^2x", is that a typo of "(1.5^2)x" or did you mean 1.5^(2x)"? The second one is straight wrong).

Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by not2b on Monday May 11, 2020 @06:33PM (#23147950)
1 out of 421 NYC residents have died, based on today's numbers, and recent serological tests estimated that 20% of residents were exposed. If that's right, then the death rate would be about 1/84, or about 1.2%. But I've seen other claims that the exposure rate in NYC is higher, which would give a lower fatality rate.
Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by taeric on Monday May 11, 2020 @09:49PM (#23149706)
Don't forget to factor this breaking through to long term care facilities. From the last I looked at this, if it had not hit long term care, the number of deaths would have been low enough that it may have gone undetected longer. (In WA, 92% of the deaths are still folks over sixty! I don't know the numbers for how many of them were in long term care.)

Which is to say, you can't just look at the population death rate and really appreciate just how dangerous this is for older populations. The CFR for over sixty is a staggering 15% in WA. That is ridiculously high and completely masked if you look at all cases.

Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by postingawayonhn on Tuesday May 12, 2020 @02:09AM (#23151001)
> Don't forget to factor this breaking through to long term care facilities.

If they're not taking any precautions (because there's no knowledge of the virus in the community) then it can spread to those types of facilities very easily. In New Zealand where only 1,500 people have have COVID-19 (likely to be very accurate, 200,000 tests have been conducted) there's already been two outbreaks in nursing homes.

Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by taeric on Tuesday May 12, 2020 @09:22AM (#23153677)
Certainly. I am not implying that we should just let it run its course. Just as I would not let any disease we have a vaccine for loose in a nursing home without the vaccine.

I just think the total IFR actually undersells how dangerous this is.

Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by raducu on Tuesday May 12, 2020 @02:56AM (#23151204)
A friend of a friend got released from the hospital, she had covid-19 and was searching for an oxygen concentrator for her (permanent?) lung damage.

She's 29 and otherwise healthy. I'm sure we would have noticed this disease without the high mortality rate among the elderly.

Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by taeric on Tuesday May 12, 2020 @09:20AM (#23153661)
I'm sure we would have noticed. I'm not sure we would have noticed as quickly. We certainly would not have tested to find that nearly a quarter of NYC could have it.

Yes, it can do damage and is very dangerous for an at risk group. No, we don't know who that is, yet. Age clearly proxies for a risk factor. But which one?

Unless you are wanting to claim that no children have gotten this. Which, seems highly unlikely. (Or is the risk whether it will provoke an immune response?)

Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by nitrogen on Monday May 11, 2020 @08:40PM (#23149282)
If I'm interpreting this[0] right, it looks like the normal death rate is 3.51 per 421 people per year. 1/421 in NYC (is that just COVID cases or all excess deaths?) is over much less than a year, so it seems fairly serious.

But I also had a truly "weird cold" go through my workplace early this year in SFBA, so I still have to wonder what that was.

[0] https://www.wolframalpha.com/input/?i=us+death+rate+*+421+pe...

Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by drran on Tuesday May 12, 2020 @02:31AM (#23151086)
Average death rate is 1/65-1/80 per year, or 1.5-1.2%, depending on country life expectancy.
Re:New Abbott SARS-CoV-2 antibody test has 99.90% specificit... by xyhopguy on Monday May 11, 2020 @05:56PM (#23147580)
That's a great point although obviously its very hard to estimate something that has a horizon of atleast a month. the bay area did shut down quite a bit earlier, it could be that the lack of deaths is simply due to a better response.