It might make certain large organizations reluctant to bring him on board, but I imagine those organizations wouldn't be places he'd like to work. I think there will be other large organizations that would be more inclined to hire him; if nothing else, this makes hiring him a good branding exercise with other employees.

Maybe I'm overly optimistic, but I'd like to think at least when you are talented enough, sticking true to your nature probably serves you better than to do otherwise.