I've tried multiple monitors a number of times through the years, and it's only been a net benefit when doing things like streaming and/or presenting via video conference (so you can have a preview monitor / live chat separate).

Other than that, my brain and neck both work a lot better with one large 4K display (currently 27" but I've been thinking about going 32").

I made this switch. After a couple years of a single (but larger) display, I can enthusiastically say I like it much better. I have the Dell UP3216Q.

and this is why I still use two 20-inch 4:3-ratio monitors in portrait mode (combined screen is 2400x1600) -- I can look at each monitor with minimal neck movement and the viewing angle for each half is independent. when i've tried a single, curved ultra-wide I still felt like the outer third on each side was a tilted away too much