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Re:The first human trial in Europe of a coronavirus vaccine ... by refurb on Thursday April 23, 2020 @08:53PM (#22963463)
I'm not disagreeing with your logic. The risk would be reasonably low if the subjects are young and healthy.

However, you can still get similar information by just dropping the control arm in this trial. Give a bunch of people the vaccine and exposed them to the virus. Sure it's not as good as having an untreated control arm, but you're also reducing the risk of someone in the control group dying.

Re:The first human trial in Europe of a coronavirus vaccine ... by Wowfunhappy on Thursday April 23, 2020 @09:54PM (#22963831)
The data is of very little use without a control. You could compare it to overall Coronavirus death rates, but those numbers are biased in all sorts of ways (for instance, fully asymptomatic cases).
Re:The first human trial in Europe of a coronavirus vaccine ... by refurb on Thursday April 23, 2020 @10:15PM (#22963953)
I would disagree with "very little use". Uncontrolled trials are done all the time. You basically collect "nature history" data and compare it to that.

In addition, the mechanism of vaccines is very well know. You can vaccinate and measure antibody formation.

You could still develop a vaccine without a control and have confidence that it works.

Re:The first human trial in Europe of a coronavirus vaccine ... by astura on Friday April 24, 2020 @12:37AM (#22964695)
Pretty sure uncontrolled trials are common at the latest stages of drug development. It's called a single-arm trial.

Source: I once participated in a phase III open-label single-arm trial.

Re:The first human trial in Europe of a coronavirus vaccine ... by s1artibartfast on Friday April 24, 2020 @01:36AM (#22964979)
They exist, but are usually not sufficient to support a drug or vaccine approval.

The standard is two well controlled studies, but additional open label trials may be used to address specific health authority concerns.

If you are interested, you can look up the other trials the drug may have gone through.